Sibilla in Spain: Dienogest Ethinylestradiol Pill
Medically Reviewed by Dr. Pedro Yelamo Vera, MD
Licensed Physician No. 484814280 · Official Medical College of Bizkaia (Spain)Last reviewed: 29 October 2026
Sibilla is a dienogest ethinylestradiol combined pill, on prescription in Spain. Uses, blood clot warning signs, who should avoid it and UK equivalents.
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Dr. Pedro Yelamo Vera is an independent, bilingual GP licensed in Spain. Book a 15-minute video consultation in English or Spanish for €50, with a private electronic prescription issued under Spanish law when clinically appropriate.
Sibilla is a combined contraceptive pill sold in Spain. Each active tablet holds dienogest, a progestogen, and ethinylestradiol, an oestrogen. The dienogest ethinylestradiol mix stops an egg being released each month. In Spain it is also licensed for moderate acne in women who want a pill. It needs a prescription, and it is not sold in the UK under this name.
- Sibilla is a combined pill: dienogest plus ethinylestradiol, an oestrogen.
- It needs a prescription in Spain. Sibilla Diario is the same pill with inactive tablets added.
- Like all combined pills, it slightly raises the risk of blood clots. Know the warning signs.
- It is not for everyone: migraine with aura, past clots and smoking over 35 can rule it out.
Dr. Pedro Yelamo Vera is a GP licensed in Spain (Colegiado No. 484814280).
For a medical emergency, call 112 or go to the nearest local emergency department. Do not wait for a video consultation or an online reply.
What is Sibilla used for?
The leaflet gives two uses:
- Preventing pregnancy. The two hormones stop an egg being released each month.
- Moderate acne in women who also want a pill, when creams or antibiotic tablets have not worked. The leaflet says the skin often takes a few months to improve.
Sibilla comes in two kinds of pack. Both hold the same active tablets. Each pack has a set daily routine, which the leaflet explains.
- Sibilla: 21 active tablets, then a week with no tablets.
- Sibilla Diario: 21 active tablets and 7 green inactive tablets, so there is no week without tablets.
In the pill-free or inactive week you usually have a bleed, a bit like a light period.
Is Sibilla sold in the UK or the US?
Not under this name, and we could not confirm a direct match. The same mix is sold in several European countries, often as Valette. The Pharmaceutical Journal reports that Valette is not marketed in the UK. In the US, dienogest is only sold with a different oestrogen, estradiol valerate, as Natazia.
| Name | What it is | Where |
|---|---|---|
| Sibilla, Sibilla Diario | Dienogest + ethinylestradiol | Spain (prescription) |
| Danielle, Donabel, Ceciliana, Adieris | Dienogest + ethinylestradiol generics | Spain (prescription) |
| No matching product found | Not marketed under these names | UK |
| Natazia | Dienogest + estradiol valerate (a different pill) | US |
If you used another combined pill at home, the hormones may differ. Bring the box to your visit so a doctor can compare the ingredients.
Do you need a prescription for Sibilla in Spain?
Yes. The AEMPS CIMA database lists Sibilla, Sibilla Diario and every other Spanish dienogest and ethinylestradiol pill as prescription-only. A prescription from another country is not accepted at a Spanish pharmacy. Our guide to birth control prescriptions in Spain explains who can write one.
Need to renew your pill, or not sure a combined pill is still right for you?
You can book a video visit with a GP licensed in Spain, in English or Spanish. He checks your blood pressure readings, migraines and clot risk first.
How big is the blood clot risk?
All pills with an oestrogen slightly raise the risk of a clot in a vein. The leaflet gives yearly figures per 10,000 women. About 2 women who use no pill get a clot. The figure is 5 to 7 on some older pills, and about 8 to 11 on Sibilla. The risk is still small. It is highest in the first year, or when you restart after a break of a month or more.
Some things raise your risk. These include being very overweight, being over 35, smoking and having just had a baby. A close relative who had a clot young counts too. Long flights, surgery or a leg in plaster raise it for a while. Tell any doctor who plans an operation that you take the pill.
Call 112 straight away if you notice any of these:
- Pain or swelling in one leg, often with warmth or a change in skin colour.
- Sudden breathlessness, chest pain that is worse when you breathe in, or coughing up blood.
- A sudden, severe headache unlike your usual ones.
- Sudden loss or blurring of sight, trouble speaking, or weakness on one side of the face or body.
Who should not take a combined pill like Sibilla?
The leaflet and the NHS list several reasons. Do not take it if you have, or have had:
- A blood clot, or an inherited clotting problem.
- A heart attack, stroke or angina.
- Migraine with aura (warning signs such as flashing lights).
- Very high blood pressure, or diabetes with damage to blood vessels.
- Severe liver disease, a liver tumour, or breast cancer.
- Bleeding from the vagina that has not been explained.
It is also not advised if you smoke and are over 35, or while breastfeeding. A pill without oestrogen may suit you better. Our contraception page explains the other options.
Which medicines can make Sibilla less reliable?
- Some epilepsy medicines, such as carbamazepine, phenytoin, topiramate and barbiturates.
- Rifampicin, used for tuberculosis.
- Some HIV medicines, and griseofulvin, an antifungal.
- St John's wort, a herbal remedy.
Some hepatitis C medicines must not be taken with it at all. Sibilla can also weaken lamotrigine. Always tell a doctor or pharmacist that you take the pill. If you miss pills, or are sick soon after one, the leaflet explains when you need extra protection.
If the pill may have failed after sex, our morning-after pill guide explains emergency contraception in Spain.
What Sibilla does not do
- It does not protect against STIs, including HIV. Use condoms for that.
- It is not emergency contraception.
- It is not a first step for acne. Creams and other treatments come first.
Side effects and when to see a doctor
Headache and sore breasts are the most common side effects. Others include nausea, mood changes, spotting between periods and changes in weight. Many settle within the first few months. See a doctor soon if:
- You feel low, or your mood changes.
- Bleeding between periods goes on for months, or starts after months of normal use.
- You miss two bleeds in a row, as you could be pregnant.
- Your face, tongue or throat swells. If you also struggle to breathe, call 112.
Talking it through with a doctor by video
Dr. Yelamo is a GP licensed in Spain. He sees adults, children and pregnant patients by video, every day from 07:30 to 20:30 (Spain time). In the visit he will:
- Ask about migraines, smoking, past clots and clots in your family.
- Ask for a recent blood pressure reading and your weight.
- Compare your current pill with what is sold in Spain.
- Explain whether a combined pill, a pill without oestrogen or another method fits you.
He does not promise any test or prescription before the visit. Where clinically appropriate, following a genuine evaluation. Treatment and prescriptions are issued solely at the doctor's discretion based on evidence-based clinical guidelines.
A prescription is never guaranteed: it is issued only where clinically appropriate after a genuine evaluation, as a private electronic prescription under Spanish law. This service is for urgent, non-emergency care. In an emergency, call 112.
See how the Urgent Care video visit works. It lasts 15 minutes and costs €50.
This guide is general information. It does not replace the package leaflet or the advice of your doctor or pharmacist.
Frequently asked questions
What is Sibilla?
A combined contraceptive pill sold in Spain. Each active tablet holds dienogest, a progestogen, and ethinylestradiol, an oestrogen.
Is there a UK or US version of Sibilla?
Not that we could confirm. The same mix is sold across Europe, often as Valette, but Valette is not marketed in the UK. In the US, dienogest only comes with a different oestrogen.
Do I need a prescription for Sibilla in Spain?
Yes. CIMA lists Sibilla, Sibilla Diario and the other Spanish dienogest and ethinylestradiol pills as prescription-only.
What is the difference between Sibilla and Sibilla Diario?
The active tablets are the same. Sibilla has 21 tablets and a week with no pills. Sibilla Diario adds 7 inactive tablets, so there is no week without tablets.
What are the warning signs of a blood clot on the pill?
A painful or swollen leg, chest pain, sudden breathlessness, a sudden severe headache, or problems with sight or speech. Call 112 straight away.
Does Sibilla protect against STIs?
No. It does not protect against HIV or other sexually transmitted infections. Only condoms help with that.
Sources
- AEMPS CIMA: Sibilla package leaflet
- AEMPS CIMA: Sibilla Diario package leaflet
- NHS: Who can take the combined pill
- MedlinePlus: Birth control
Related guides
Medical Citations & Sources
This content is written and reviewed by a licensed physician with reference to the following official health authorities.
