Varidasa in Spain: Streptokinase Streptodornase Tablets
Medically Reviewed by Dr. Pedro Yelamo Vera, MD
Licensed Physician No. 484814280 · Official Medical College of Bizkaia (Spain)Last reviewed: 29 October 2026
Varidasa is a streptokinase streptodornase tablet, prescription-only in Spain. What it is for, who must avoid it and what helps bruises and swelling.
You don't have to figure this out alone
Dr. Pedro Yelamo Vera is an independent, bilingual GP licensed in Spain. Book a 15-minute video consultation in English or Spanish for €50, with a private electronic prescription issued under Spanish law when clinically appropriate.
Varidasa is a Spanish tablet that combines two enzymes, streptokinase and streptodornase. Its leaflet lists it for swelling and bruising after an injury, and for some infections alongside antibiotics. It is still authorised and on sale in Spain, but only on prescription. It can raise the risk of bleeding, so it is not right for everyone.
- Varidasa contains streptokinase and streptodornase, two enzymes made by bacteria.
- It is prescription-only in Spain. It is not for anyone under 18, or during pregnancy or breastfeeding.
- It must not be used by people with bleeding problems, low platelets or severe high blood pressure that is not controlled.
- For most bruises and sprains, rest, cold and raising the limb are the first steps.
Dr. Pedro Yelamo Vera is a GP licensed in Spain (Colegiado No. 484814280).
For a medical emergency, call 112 or go to the nearest local emergency department. Do not wait for a video consultation or an online reply.
What is Varidasa used for?
The Spanish leaflet lists two uses:
- Swelling after an injury, with fluid build-up (oedema) or a bruise (haematoma).
- Inflammation from an infection, always together with an antibiotic.
It comes as orange tablets with a score line. The doctor or the leaflet sets how many to take and for how long. It is an old medicine: its current Spanish leaflet dates from 2007.
How do streptokinase and streptodornase work?
Both are enzymes. Streptokinase switches on the body's own system that breaks down blood clots. Streptodornase breaks down DNA, which makes thick pus thinner. The product information says some of the enzymes are absorbed from the gut. It describes how they work, but it does not quote results from clinical trials. Ask your doctor what benefit to expect in your case.
Is there a UK or US version of Varidasa?
| Name | What it is | Where |
|---|---|---|
| Varidasa | Streptokinase + streptodornase tablets | Spain (prescription, on sale) |
| Varidase Topical | Streptokinase + streptodornase powder for wounds | Ireland: licence withdrawn in 2006 |
We could not find a streptokinase and streptodornase tablet sold in the UK or the US. If you were treated with something similar elsewhere, bring the box or a photo to the visit.
Do you need a prescription for Varidasa in Spain?
Yes. The AEMPS CIMA database lists Varidasa tablets as medicamento sujeto a prescripción médica, and as on sale. A Spanish pharmacist needs a valid prescription. See our guide on which medicines need a prescription in Spain.
A bruise, sprain or swollen ankle that worries you?
You can book a video visit with a GP licensed in Spain, in English or Spanish. He checks for warning signs and explains what will help.
Who should not take Varidasa?
- People allergic to streptokinase, streptodornase or any part of the tablet. It contains the colouring E-110, which can cause allergy.
- People with a bleeding disorder, low platelets or low fibrinogen, a clotting protein.
- People with severe high blood pressure that is not under control.
- Anyone under 18, and women who are pregnant or breastfeeding.
The leaflet also asks for care after recent surgery, a head injury, a stroke, childbirth or bleeding from the gut. The same goes for an active stomach ulcer or severe liver or kidney disease. Tell the doctor about any of these.
Which medicines does Varidasa interact with?
The main risk is bleeding. The leaflet warns about taking it with:
- Blood thinners, such as warfarin or acenocoumarol (Sintrom).
- Medicines that act on platelets, such as clopidogrel.
- Anti-inflammatories, especially aspirin and indometacin.
Many people reach for ibuprofen after a knock. Do not mix it with Varidasa without asking. Our ibuprofen guide explains that medicine in Spain.
Does Varidasa raise blood pressure or eye pressure?
People often ask this. The leaflet does not list raised blood pressure or raised eye pressure as side effects. It does say that people with severe, uncontrolled high blood pressure must not take it. It also asks for care in people whose high blood pressure has damaged the back of the eye. If you have glaucoma or high blood pressure, mention it.
Side effects and when to see a doctor
The body often makes antibodies against streptokinase. This can make a later course work less well. Less common effects are allergy, feeling sick, diarrhoea, stomach pain, being sick, headache, back or muscle pain, chills, fever and tiredness. Liver tests can rise for a short time. See a doctor if:
- You get a rash, itching or hives while taking it.
- You bruise or bleed more easily than usual.
- A swelling grows, gets hot and red, or you get a fever.
- The pain or swelling is no better after a few days.
Call 112 if your face, lips or throat swell, or you struggle to breathe. Also call 112 if you vomit blood, pass black stools or have a severe headache. After an injury, call 112 if a limb is bent out of shape, numb, cold or blue.
What helps a bruise or a sprain?
Most bruises fade on their own in about two weeks. For bruises, sprains and swelling, the NHS and MedlinePlus advise:
- Rest the injured part for the first few days.
- Cold: a cold pack or ice wrapped in a cloth, never straight on the skin.
- Raise the limb above the level of the heart when you can.
- Support it with a bandage during the day if it is swollen.
- Avoid heat, alcohol and massage in the first couple of days.
A pharmacist or doctor can suggest a pain reliever that suits you. Our swollen ankles page explains when swelling needs a closer look.
Talking it through with a doctor by video
Dr. Yelamo is a GP licensed in Spain. He sees adults, children and pregnant patients by video, every day from 07:30 to 20:30 (Spain time). In the visit he will:
- Ask how the injury happened and look at the swelling or bruise on camera.
- Check for signs of a break, a clot or an infection that need an in-person exam.
- Review your other medicines, above all blood thinners and anti-inflammatories.
- Explain which self-care steps, pain relief or follow-up suit you.
He does not promise any test or prescription before the visit. Where clinically appropriate, following a genuine evaluation. Treatment and prescriptions are issued solely at the doctor's discretion based on evidence-based clinical guidelines.
A prescription is never guaranteed: it is issued only where clinically appropriate after a genuine evaluation, as a private electronic prescription under Spanish law. This service is for urgent, non-emergency care. In an emergency, call 112.
See how the Urgent Care video visit works. It lasts 15 minutes and costs €50.
This guide is general information. It does not replace the package leaflet or the advice of your doctor or pharmacist.
Frequently asked questions
What is Varidasa?
A Spanish tablet that contains two enzymes, streptokinase and streptodornase. Its leaflet lists it for swelling and bruising after an injury, and for some infections alongside antibiotics.
Is Varidasa still sold in Spain?
Yes. The AEMPS CIMA database lists Varidasa tablets as authorised and on sale, as a prescription-only medicine.
Does Varidasa raise blood pressure or eye pressure?
Its leaflet does not list raised blood pressure or eye pressure as side effects. It must not be used by people with severe high blood pressure that is not under control.
Can I take Varidasa with aspirin or ibuprofen?
Tell the doctor first. The leaflet warns that aspirin, other anti-inflammatories and blood thinners can raise the risk of bleeding with Varidasa.
Can children take Varidasa?
No. The leaflet says it is not recommended under 18, because its safety and effect have not been shown in young people.
What helps a bruise or swelling without medicine?
Rest, a cold pack wrapped in a cloth and raising the area help most. A pharmacist can advise on a pain reliever that suits you.
Sources
- AEMPS CIMA: Varidasa package leaflet
- AEMPS CIMA: Varidasa product information
- MedlinePlus: Bruises
- NHS: Sprains and strains
Related guides
Medical Citations & Sources
This content is written and reviewed by a licensed physician with reference to the following official health authorities.
